Trazodone as a Fibromyalgia Treatment

By Adrienne Dellwo, Fibromyalgia & Chronic Fatigue Guide – Wednesday September 15, 2010

Research Brief

A small study just published in the online version of BMC Musculoskeletal Disorders shows that the drug trazodone may be an effective treatment for fibromyalgia. However, researchers warn of a serious side effect.

Researchers say trazodone made participants sleep better and longer, improved how they felt and functioned, and lessened their anxiety and depression. They also report tachycardia (rapid heart beat) in more than 20% of patients and recommend close monitoring. Tachycardia is a known side effect of this drug, but it surprised researchers by its frequency and severity in this study.

Trazodone is sold under the brand name Desyrel. It’s classified as an atypical antidepressant, but it has some factors in common with both tricyclics (such as amitriptyline or doxepin) and SSRIs (fluoxetine, paroxetine.) It’s a more effective sedative than other antidepressants and is often prescribed as a sleep aid. It also blocks some nerve transmissions.

In addition to tachycardia, side effects include:

  • Feeling faint or lightheaded
  • Falls
  • Sexual dysfunction, including painful erections
  • Suicidal thoughts or other mood changes
  • Trembling
  • Constipation
  • Headache
  • Muscle pain
  • Nausea and vomiting

Get more information on this drug: Trazodone.

About Michelle Arbore

I am 36 years old, married for 8 years and have an almost 3 year old, Michael Richard. We also have two cats (Anibel & Mama). I own my own social media management and coaching business that allows me to work from home. I like to read, listen to music, take photos, learn new things, shop, watch TV and spend time with family and friends. I also suffer from Fibromyalgia. I have suffered from this disease for over 15 years now. I started my blog so I could have a place to vent about what I am feeling. It has turned into a place where I post information about this disease, talk about books that I am reading about Fibro, and getting to meet other people who suffer from this.
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2 Responses to Trazodone as a Fibromyalgia Treatment

  1. Hi! I’ve taken Trazadone for about two years now and it does help me sleep better and feel better, except when I get the occasional flare-up. But who doesn’t? :0) I have had a faster heartbeat, but I also take Savella and that can cause quick heart rate and sweating. My doctor has treated the rapid heart rate with atenolol and that works like a charm. I recommend it to those having problems with sleeping. Like Leana said, I don’t think it helps much with the pain, but you do get a deeper sleep with it.

  2. Leana says:

    I took this in a recent trial study at a clinic. I slept like a baby but the morning grogginess wasn’t so great. I didn’t have any side effects luckily. I’m not sure it helped with alot of the pain but I definitely did sleep better. Soon after the study I discovered melatonin and changed my diet complete. AMAZING difference! I just started a blog so that I could post some of the information I’ve found…

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